반응 #444964

반응 방정식

2-Methyl-3-furancarboxylic acid ethyl ester

sodium hydroxide

→

2-methyl-3-furancarboxylic acid

수율 67.2%

용매

ethanol

반응 조건

후처리

1. 1
   농축concentrated under reduced pressure
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water
3. 3
   세척washed with diethyl ether
4. 4
   추출extracted with ethyl acetate
5. 5
   세척The extract was washed with water and saturated aqueous sodium chloride
6. 6
   건조dried over anhydrous magnesium sulfate
7. 7
   농축concentrated under reduced pressure
8. 8
   기타Precipitated crystals
9. 9
   여과were collected by filtration

실험 절차

2-Methyl-3-furancarboxylic acid ethyl ester (10 g) was dissolved in ethanol (70 ml), and 1N aqueous sodium hydroxide (78 ml) was added. The mixture was stirred at room temperature and concentrated under reduced pressure. The residue was dissolved in water and washed with diethyl ether. The aqueous layer was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Precipitated crystals were collected by filtration to give 2-methyl-3-furancarboxylic acid (5.5 g) as crystals.

출처