반응 #44486

반응 방정식

solution

4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one

Dess-Martin periodinane

→

title compound

1-Cycloheptyl-4,4-dimethyl-5-oxo-pyrrolidine-3-carbaldehyde

용매

methanol

반응 조건

후처리

1. 1
   기타The solvent was evaporated in vacuo
2. 2
   workup.STIRRINGstirred at room temperature for two hours
3. 3
   기타The reaction was quenched with 10% sodium bisulfite
4. 4
   추출extracted with dichloromethane
5. 5
   세척The organic phase was washed with water
6. 6
   건조dried with MgSO4
7. 7
   여과filtered
8. 8
   기타evaporated in vacuo

실험 절차

To a solution of Example 1D (0.168 mg, 0.475 mmoles) in methanol (1.5 mL), two drops of 12M HCl was added and stirred for one hour. The solvent was evaporated in vacuo. The residue was taken in dichloromethane (2.5 mL) and Dess-Martin periodinane (0.25 gm, 0.593 mmoles) was added and stirred at room temperature for two hours. The reaction was quenched with 10% sodium bisulfite and extracted with dichloromethane. The organic phase was washed with water, dried with MgSO4, filtered, and evaporated in vacuo to provide the title compound.

출처