반응 #44454

반응 방정식

acetic acid

4-bromo-2-nitro-1-phenoxybenzene

→

crude compound

수율 91.7%

5-Bromo-2-phenoxybenzeneamine

수율 91.7%

용매

water

반응 조건

후처리

1. 1
   온도After cooling to room temperature the reaction mixture
2. 2
   여과was filtered
3. 3
   추출extracted with toluene
4. 4
   세척The toluene solution was washed with water (3×) and brine
5. 5
   건조dried (Na2SO4)
6. 6
   기타evaporated

실험 절차

Iron powder (3 g, 53.4 mmol) and acetic acid (10 mL) were added to a stirred suspension of 4-bromo-2-nitro-1-phenoxybenzene (3.1 g, 9.5 mmol) in water (25 mL) of 60° C. The reaction mixture was heated to 80° C. and stirred for 30 min. After cooling to room temperature the reaction mixture was filtered and extracted with toluene. The toluene solution was washed with water (3×) and brine, dried (Na2SO4) and evaporated to give the crude compound (2.3 g, 87%). Data: (m/z)=264+266 (M+H)+.

출처