반응 #444192

반응 방정식

water

5-(4-chlorobutylthio)imidazo[1,2-a]pyridine

oxazolidine-2,4-dione potassium salt

sodium iodide

→

desired product

3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]-oxazolidine-2,4-dione

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   추출extracted with ethyl acetate
3. 3
   세척The organic layer was washed with water
4. 4
   기타dried
5. 5
   workup.DISTILLATIONafter which the solvent was distilled off
6. 6
   기타The residue was purified by column chromatography (eluent: ethyl acetate)

실험 절차

To a solution of 6.30 g (26.2 mmol) of 5-(4-chlorobutylthio)imidazo[1,2-a]pyridine and 3.64 g (26.2 mmol) of oxazolidine-2,4-dione potassium salt in 100 ml of N,N-dimethylformamide, 3.92 g (26.2 mmol) of sodium iodide was added, followed by stirring at 80° C. for 16 hours. After cooling, the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water and dried, after which the solvent was distilled off. The residue was purified by column chromatography (eluent: ethyl acetate) to yield 5.70 g (71.4%, light orange crystal) of the desired product.

출처