반응 #44412

반응 방정식

2,6-dichloropyrazine

1H-benzimidazole-5-carboxamide

cesium carbonate

→

1-(6-chloropyrazin-2-yl)-1H-benzimidazole-6-carboxamide

용매

DMF

ethyl acetate

반응 조건

후처리

1. 1
   온도The solution was cooled to RT
2. 2
   여과filtered
3. 3
   세척The solid material was washed with chloroform-methanol (20 mL, 4:1)
4. 4
   농축the combined filtrates concentrated in vacuo
5. 5
   기타The residue thus obtained (3.02 g)
6. 6
   기타was used without further purification

실험 절차

A mixture of 2,6-dichloropyrazine (2.0 g, 13.4 mmol), 1H-benzimidazole-5-carboxamide (2.0 g, 12.3 mmol) and cesium carbonate (5.6 g, 17.2 mmol) in DMF (10 mL) was heated at 90° C. for 3 h. The solution was cooled to RT and diluted with ethyl acetate (20 mL) and filtered. The solid material was washed with chloroform-methanol (20 mL, 4:1) and the combined filtrates concentrated in vacuo. The residue thus obtained (3.02 g) was used without further purification.

출처