반응 #44399

반응 방정식

trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-cyclohexyl-amine

ethylisocyanate

→

title compound

수율 65.0%

Trans-1-{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3-ethyl-urea

수율 65.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The solvent was removed in vacuo
2. 2
   workup.STIRRINGThe residue was stirred with water
3. 3
   여과the precipitate was filtered

실험 절차

0.56 g (1.2 mmol) trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-cyclohexyl-amine was dissolved in dry dichloromethane (20 ml), ethylisocyanate (0.1 ml, 1.3 mmol) was added and the reaction mixture was stirred at room temperature for 4 hours. The solvent was removed in vacuo. The residue was stirred with water, the precipitate was filtered, giving the title compound (0.33 g, 65%). Melting point: 235-8° C.

출처