반응 #44398

반응 방정식

trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-cyclohexyl-amine trihydrochloride

triethylamine

N,N-dimethylcarbamoylchloride

→

title compound

수율 65.0%

Trans-1-{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea

수율 65.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   여과filtered
2. 2
   세척The filtrate was washed with water (2×20 ml)
3. 3
   기타dried
4. 4
   기타evaporated in vacuo
5. 5
   기타Recrystallizing from methanol

실험 절차

1.39 g (3 mmol) trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-cyclohexyl-amine trihydrochloride was suspended in dichloromethane (100 ml), triethylamine (2.1 ml, 15 mmol) was added followed by 0.30 ml (3.3 mmol) N,N-dimethylcarbamoylchloride. The reaction mixture was stirred for 48 hours at room temperature, filtered. The filtrate was washed with water (2×20 ml), dried and evaporated in vacuo. Recrystallizing from methanol gave the title compound (0.83 g, 65%), melting at 212-4° C.

출처