반응 #443973

반응 방정식

tyrosine

tetramethylene sulfone

glutamic acid

phenylalanine

aspartic acid

→

Glu Asp Tyr Phe

용매

water

반응 조건

후처리

1. 1
   온도the mixture was heated for one-half hour
2. 2
   온도the mixture heated at 190° C. for 3 hours
3. 3
   온도the mixture heated at 190° C. for 1.5 hours
4. 4
   workup.STIRRINGAfter stirring for about 1 hour
5. 5
   여과the mixture was filtered
6. 6
   여과filtered
7. 7
   기타The pH of the slurry (at 25° C.)
8. 8
   여과The mixture was filtered
9. 9
   세척the cake washed with a small amount of water
10. 10
    기타evaporated to dryness in vacuo

실험 절차

750 ml of tetramethylene sulfone was heated to 190° C. in an inert nitrogen atmosphere in a 4 liter flask with stirring. 294 g of glutamic acid was added and the mixture was heated for one-half hour. 266 g of aspartic acid was added and the mixture heated as rapidly as possible to 190° C. and held there for 15 minutes. 362 g of tyrosine was added and the mixture heated at 190° C. for 3 hours. 330 g of phenylalanine was added and the mixture heated at 190° C. for 1.5 hours. The hot melt was then poured into 5 liters of water with vigorous stirring. After stirring for about 1 hour, the mixture was filtered and the filtrate discarded. The cake was reslurried in 5 liters of water, filtered and the cake was again reslurried in 5 liters of water. The pH of the slurry (at 25° C.) was adjusted to 8 using 40% sodium hydroxide solution. The mixture was filtered and the cake washed with a small amount of water. The washes and filtrate are combined and evaporated to dryness in vacuo to give Glu/Asp/Tyr/Phe proteinoid.

출처