반응 #44378

반응 방정식

product

(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid

product

4-bromo-2-fluoro-N,N-bis(1-methylethyl)-benzamide

sodium carbonate

→

title compound

(2S)-2-[[4′-[[bis(1-methylethyl)amino]carbonyl]-5-chloro-3′-fluoro[1,1′-biphenyl]-2-yl]oxy]-propanoic acid

용매

dioxan

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도at reflux for 24 h
3. 3
   여과filtered (hyflo)
4. 4
   농축The filtrate was concentrated in vacuo
5. 5
   기타purified by reverse phase HPLC

실험 절차

The product of step c) (200 mg), the product of step d) (200 mg), Pd(dppf)Cl2 (60 mg), sodium carbonate (350 mg) and dioxan (5 ml) were charged to a flask and heated at reflux for 24 h, then cooled to room temp and filtered (hyflo). The filtrate was concentrated in vacuo, then purified by reverse phase HPLC to give the title compound. Yield 22 mg

출처