반응 #443752

반응 방정식

N-formyl-L-aspartic acid

L-phenylalanine methyl ester

D,L-phenylalanine methyl ester

N-formyl-L-aspartic acid

D,L-phenylalanine methyl ester

→

N-formyl-α-L-aspartyl-L-phenylalanine methyl ester

용매

water

반응 조건

후처리

1. 1
   기타the condensation reaction in the aqueous phase

실험 절차

An enzymatic method for producing N-formyl-α-L-aspartyl-L-phenylalanine methyl ester by a condensation reaction between N-formyl-L-aspartic acid and L-phenylalanine methyl ester or D,L-phenylalanine methyl ester, which comprises: supplying an organic phase comprising a water-immiscible solvent containing N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester onto an aqueous phase comprising a thermolysin-like metalloprotease; proceeding the condensation reaction in the aqueous phase to produce N-formyl-α-L-aspartyl-L-phenylalanine methyl ester; and extracting the N-formyl-α-L-aspartyl-L-phenylalanine methyl ester thus produced from the aqueous phase to the organic phase.

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