반응 #4437

반응 방정식

water

4-chloro-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine

2,4,6-trimethylphenol

sodium hydride

→

6-(3,4-dimethoxyphenyl)-2-methyl-4-(2,4,6-trimethylphenoxy)pyrimidine

수율 71.2%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture was stirred at ambient temperature for 18 hours
2. 2
   추출extracted with ethyl acetate
3. 3
   세척The organic layer was washed with brine
4. 4
   건조dried over sodium sulfate
5. 5
   기타evaporated
6. 6
   기타The residue was chromatographed on silica gel eluting with chloroform

실험 절차

To a solution of 2,4,6-trimethylphenol (1.03 g) in N,N-dimethylformamide (20 ml) was added sodium hydride (60% in oil, 0.30 g), and stirred at ambient temperature for 5 minutes. To the solution was added 4-chloro-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (2.0 g), and the mixture was stirred at ambient temperature for 18 hours. The solution was poured into water (300 ml), and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate and evaporated. The residue was chromatographed on silica gel eluting with chloroform to give 6-(3,4-dimethoxyphenyl)-2-methyl-4-(2,4,6-trimethylphenoxy)pyrimidine (1.96 g).

출처