반응 #4436

반응 방정식

6-(3,4-dimethoxyphenyl)-2-methyl-4-(1-piperazinyl)pyrimidine

triethylamine

2,4-dichloro-5-sulfamoylbenzoyl chloride

→

4-[4-(2,4-dichloro-5-sulfamoylbenzoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine

수율 71.5%

용매

chloroform

반응 조건

후처리

1. 1
   세척The reaction mixture was washed with water
2. 2
   건조dried over magnesium sulfate
3. 3
   기타evaporated
4. 4
   기타The obtained mixture was chromatographed on silica gel eluting with chloroform-methanol mixture (49:1 v/v)

실험 절차

To a solution of 6-(3,4-dimethoxyphenyl)-2-methyl-4-(1-piperazinyl)pyrimidine (0.8 g) in chloroform (10 ml) were added triethylamine (0.39 ml) and 2,4-dichloro-5-sulfamoylbenzoyl chloride (0.74 g), and the mixture was stirred at ambient temperature for 20 hours. The reaction mixture was washed with water, dried over magnesium sulfate, and evaporated. The obtained mixture was chromatographed on silica gel eluting with chloroform-methanol mixture (49:1 v/v), to give 4-[4-(2,4-dichloro-5-sulfamoylbenzoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (1.03 g).

출처