반응 #44359

반응 방정식

HCl

5-chloro-2-iodophenol

methyl bromoacetate

potassium carbonate

→

sub-title compound

Methyl (4-chloro-2-iodophenoxy)acetate

용매

acetonitrile

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 2 h
3. 3
   추출the mixture was extracted with ether (three times)
4. 4
   건조The organic extracts were dried (MgSO4)
5. 5
   기타evaporated
6. 6
   기타purified by chromatography (silica, petrol ether as eluent)

실험 절차

A mixture of 5-chloro-2-iodophenol (4.95 g), methyl bromoacetate (1.85 ml) and potassium carbonate (2.79 g) in acetonitrile (20 ml) was heated under reflux for 2 h. Aq HCl was added and the mixture was extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol ether as eluent) to give the sub-title compound (5.75 g).

출처