반응 #443519

반응 방정식

1,1'-(azo-dicarbonyl)dipiperidine

3-methylimidazo-[5,4-b]pyridin-2-ylmethanol

4-hydroxybenzaldehyde

tributylphosphine

→

title compound

수율 45.2%

2-(4-Formylphenoxymethyl)-3-methylimidazo[5,4-b]pyridine

수율 45.2%

용매

toluene

반응 조건

후처리

1. 1
   기타A procedure similar to that described in Preparation 4
2. 2
   기타that the product was purified by column chromatography through silica gel
3. 3
   세척a gradient elution method

실험 절차

A procedure similar to that described in Preparation 4 was repeated, except that 500 mg of 3-methylimidazo-[5,4-b]pyridin-2-ylmethanol (prepared as described in Preparation 15), 374 mg of 4-hydroxybenzaldehyde, 0.76 ml of tributylphosphine, 773 mg of 1,1'-(azo-dicarbonyl)dipiperidine and 12 ml of toluene were used, and that the product was purified by column chromatography through silica gel, using a gradient elution method, with mixtures of ethyl acetate and methanol in ratios ranging from 1:0 to 50:1 by volume as the eluent, to give 0.37 g of the title compound, melting at 124°-125° C.

출처