반응 #44351

반응 방정식

product

1,1-dimethylethyl [[3′,5-dichloro-4′-(methylsulfinyl)[1,1′-biphenyl]-2-yl]oxy]acetate

→

title compound

[[3′,5-Dichloro-4′-(methylsulfinyl)[1,1′-biphenyl]-2-yl]oxy]acetic acid

용매

TFA

반응 조건

후처리

1. 1
   기타The solvent was removed in vacuo
2. 2
   기타the mixture was azeotroped with toluene
3. 3
   기타purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)

실험 절차

A solution of the more polar product from Example 2 step d) (35 mg) in TFA (2 ml) was stirred for 24 h. The solvent was removed in vacuo, the mixture was azeotroped with toluene and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the title compound (22 mg) as a white solid.

출처