반응 #44350

반응 방정식

product

1,1-dimethylethyl [[3′,5-dichloro-4′-(methylsulfinyl)[1,1′-biphenyl]-2-yl]oxy]acetate

TFA

→

title compound

[[3′,5-Dichloro-4′-(methylsulfonyl)[1,1′-biphenyl]-2-yl]oxy]acetic acid

반응 조건

후처리

1. 1
   기타The solvent was removed in vacuo, water
2. 2
   workup.ADDITIONwas added
3. 3
   추출the mixture was extracted with dichloromethane (three times)
4. 4
   건조The organic extracts were dried (MgSO4)
5. 5
   기타evaporated
6. 6
   기타triturated with ether

실험 절차

A solution of the product from step d) (73 mg) in TFA (3 ml) was stirred for 2 h. The solvent was removed in vacuo, water was added and the mixture was extracted with dichloromethane (three times). The organic extracts were dried (MgSO4), evaporated and triturated with ether to give the title compound (46 mg) as a white solid. M.p. 140-2° C.

출처