반응 #443464

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1,1'-(azodicarbonyl)di-piperdine

2-(3-hydroxy-propyl)-3-methylimidazo[5,4-b]pyridine

5-(4-hydroxy-benzyl)-3-triphenylmethylthiazolidine-2,4-dione

tributylphosphine

→

title compound

5-[4-{3-(3-Methylimidazo[5,4-b]pyridin-2-yl)-propoxy}benzyl]-3-triphenylmethyl-thiazolidine-2,4-dione

용매

toluene

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후처리

1. 1
   기타A procedure similar to that described in Preparation 4

실험 절차

A procedure similar to that described in Preparation 4 was repeated, except that 750 mg of 2-(3-hydroxy-propyl)-3-methylimidazo[5,4-b]pyridine (prepared as described in Preparation 34), 1.83 g of 5-(4-hydroxy-benzyl)-3-triphenylmethylthiazolidine-2,4-dione, 0.98 ml of tributylphosphine, 990 mg of 1,1'-(azodicarbonyl)di-piperdine and 20 ml of toluene were used, to give the title compound as a crude product. This crude product was purified by column chromatography through silica gel, using a gradient elution method, with mixtures of hexane and ethyl acetate in ratios ranging from 1:1 to 0:1 by volume as the eluent, to give 550 mg of the title compound, melting at 76°-81° C.

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