반응 #44346

반응 방정식

sodium thiomethoxide

5-bromo-2-fluorobenzotrifluoride

water

→

sub-title compound

수율 68.3%

4-bromo-1-(methylthio)-2-(trifluoromethyl)-benzene

수율 68.3%

용매

DMF

반응 조건

후처리

1. 1
   추출extracted with isohexane
2. 2
   세척The organics were washed with brine
3. 3
   기타dried
4. 4
   농축concentrated in vacuo

실험 절차

A mixture of sodium thiomethoxide (317 mg) and 5-bromo-2-fluorobenzotrifluoride (1.0 g) in DMF (4 ml) was heated at 50° C. for 1 h then poured into water and extracted with isohexane. The organics were washed with brine, dried and concentrated in vacuo to give the sub-title compound (762 mg).

출처