반응 #44339

반응 방정식

ethyl N-piperazinecarboxylate

2-chloroacetonitrile

K2CO3

→

4-Cyanomethyl-piperazine-1-carboxylic acid ethyl ester

용매

CH3CN

반응 조건

후처리

1. 1
   기타The golden yellow solution was evaporated to dryness
2. 2
   추출The residue was extracted with CH2Cl2/H2O
3. 3
   건조dried with MgSO4
4. 4
   농축concentrated

실험 절차

To a solution of 3 g (19.0 mmol) of ethyl N-piperazinecarboxylate in 25 mL of CH3CN was added 1.57 g (1.32 mL 20.1 mmol) of 2-chloroacetonitrile and 15.6 g (95 mmol) K2CO3.1½H2O. The suspension was stirred at room temperature for 16 hours. The reaction was analyzed using TLC (35% Ethyl acetate/Hexanes, product r.f. 0.38 vs. sm r.f. of 0.02). The analysis indicated the reaction was complete. The golden yellow solution was evaporated to dryness. The residue was extracted with CH2Cl2/H2O, dried with MgSO4, and concentrated.

출처