반응 #44316

반응 방정식

N-BOC-1,4-diaminobutane

maleic anhydride

→

title compound

(4-Maleimidyl-butyl)-carbamic acid tert-butyl ester

용매

toluene

반응 조건

후처리

1. 1
   온도the solution heated
2. 2
   온도at reflux under Dean-Stark conditions for two days
3. 3
   기타The solvent was removed
4. 4
   기타the residue purified by silica column chromatography
5. 5
   세척eluting with 25-40% ethyl acetate in hexane

실험 절차

To a solution of N-BOC-1,4-diaminobutane (8.324 g, 0.044 mol) in dry toluene (50 ml) was added maleic anhydride (4.336 g, 0.044 mol) and the solution heated at reflux under Dean-Stark conditions for two days. The solvent was removed and the residue purified by silica column chromatography eluting with 25-40% ethyl acetate in hexane to give the title compound, 1.461 g, 12%, as a white solid.

출처