반응 #44308
ord-0d1d811887594b48876707271c6f6132
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타A reactor equipped with an exhaust vent
- 2기타followed by polymerization at 190° C. for 24 hours
- 3기타After the reaction
- 4기타purified by precipitation in methanol
실험 절차
A reactor equipped with an exhaust vent and a thermometer was charged with 263 g of L-lactide (reagent, supplied by SIGMA-ALDRICH JAPAN K.K.), 42 g of glycollide (prepared under the same conditions as those in Example 1), 194 g of ε-caprolactone (reagent, supplied by TOKYO CHEMICAL INDUSTRY CO., LTD.) and 0.01 g of tin octanoate (reagent, supplied by SIGMA-ALDRICH JAPAN K.K.) as a catalyst, and the pressure inside the reactor was reduced to 1×10−3 mmHg with a vacuum pump, followed by polymerization at 190° C. for 24 hours. After the reaction, a copolymer was dissolved in chloroform and purified by precipitation in methanol, to give a lactic acid/glycolic acid/ε-caprolactone copolymer.