반응 #44282

반응 방정식

6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline

triethylamine

N,N-dimethylethanolamine

→

title compound

수율 74.0%

N,N-dimethyl-2-{[1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]oxy}ethanamine

수율 74.0%

용매

n-butanol

반응 조건

후처리

1. 1
   농축concentrated
2. 2
   기타The crude product was purified by flash chromatography
3. 3
   기타a Horizon purification system on a 25S column
4. 4
   세척eluting with chloroform/7 N ammonia in methanol (0.1-5%)

실험 절차

A mixture of 6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline, (100, 0.293), triethylamine (123 μL, 0.879 mmol), N,N-dimethylethanolamine (959 μL, 0.586 mmol) in n-butanol (3.0 mL) was heated in the microwave at 120° C. for 20 minutes, then concentrated. The crude product was purified by flash chromatography using a Horizon purification system on a 25S column eluting with chloroform/7 N ammonia in methanol (0.1-5%) to afford the title compound (75 mg, 74%).

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