반응 #442804

반응 방정식

2-amino-9-(4-methylphenyl)acridine

compound 12d

2-amino-9-(4-methylphenyl)acridine

methanesulfonyl chloride

diazabicyclo[2.2.2]octane

→

2-[N,N-bis(methanesulfonyl)amino]-9-(4-methylphenyl)acridine

용매

acetonitrile

반응 조건

후처리

1. 1
   온도the solution heated for 2 hours
2. 2
   온도under reflux
3. 3
   여과filtration
4. 4
   workup.ADDITIONthe red filtrate added dropwise to 1000 pbv of 0.5% strength ammonia solution
5. 5
   여과the precipitate was filtered off by suction
6. 6
   기타crystallized from 135 pbv of ethanol

실험 절차

5.68 pbw of 2-amino-9-(4-methylphenyl)acridine (compound 12d) were dissolved with 20.3 pbw of methanesulfonyl chloride and 22.4 pbw of diazabicyclo[2.2.2]octane in 120 pbv of acetonitrile and the solution heated for 2 hours under reflux. After cooling to 20° C., filtration was carried out and the red filtrate added dropwise to 1000 pbv of 0.5% strength ammonia solution. After standing overnight, the precipitate was filtered off by suction and crystallized from 135 pbv of ethanol. Yield: 1.76 pbw (20% of theory), light yellow needles. Mp.: 217°-219° C.

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