반응 #44262

반응 방정식

quinolin-6-ylmethanamine

3,5-dibromopyrazin-2-amine

di-isopropylethylamine

→

6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine

수율 49.0%

용매

dichloromethane ethanol

반응 조건

후처리

1. 1
   여과the resulting suspension was filtered
2. 2
   세척The precipitate was washed sequentially with water and ether and air
3. 3
   기타dried

실험 절차

A mixture of quinolin-6-ylmethanamine (13 g, 82 mmol), 3,5-dibromopyrazin-2-amine (21 g, 82 mmol) and di-isopropylethylamine (16 mL, 89 mmol) was heated to 130° C. for five hours. The reaction was diluted with dichloromethane:ethanol (9:1) and the resulting suspension was filtered. The precipitate was washed sequentially with water and ether and air dried to afford 6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine (13 g, 49%).

출처