반응 #44233

반응 방정식

methylhydrazine

ethyl pyruvate

MgSO4

→

desired product

수율 94.0%

ethyl 2-(2-methylhydrazono)propanoate

수율 94.0%

용매

CHCl3

CHCl3

반응 조건

후처리

1. 1
   여과the reaction mixture was filtered
2. 2
   농축The filtrate was concentrated under reduced pressure

실험 절차

To a suspension of ethyl pyruvate (37.8 mL, 338 mmol) and MgSO4 (40.8 g, 339 mmol) in CHCl3 (500 mL) was added a solution of methylhydrazine (18.0 mL, 332 mmol) in CHCl3 (100 mL) at 0° C. The reaction mixture was warmed to room temperature. After stirring for 24 hours at room temperature, the reaction mixture was filtered. The filtrate was concentrated under reduced pressure to give 44 g (94%) of the desired product that was used directly without further purification.

출처