반응 #442095

반응 방정식

dihydropyran

p-toluenesulfonyl chloride

17β-hydroxy-4-androstene

product

→

17β-tetrahydropyranyloxy-4-androstene

용매

ethyl ether

반응 조건

후처리

1. 1
   세척washed with a 20% pyridine water mixture twice
2. 2
   건조water, then brine, and dried
3. 3
   기타evaporated
4. 4
   기타to yield a pale yellow oil which
5. 5
   기타crystallizes (8.5 g)

실험 절차

To 30 ml of dihydropyran containing 450 mg of p-toluenesulfonyl chloride is added 6.0 g of the product of Step B and the solution is stirred at room temperature for 1 hour. The solution is the diluted with ethyl ether and washed with a 20% pyridine water mixture twice, and then water, then brine, and dried and evaporated to yield a pale yellow oil which crystallizes (8.5 g), and has a m.p. of 92°-96° C.

출처