반응 #442005

반응 방정식

ethanol

sodium ethoxide

phenol

2,4,6-trichloro-7,8-dimethoxyquinazoline

→

2,6-dichloro-7,8-dimethoxy-4-ethoxyquinazoline

반응 조건

후처리

1. 1
   온도The mixture is heated
2. 2
   여과the precipitate collected by filtration
3. 3
   세척The cake is washed with water
4. 4
   건조cold ethanol, dried
5. 5
   기타recrystallized from ethanol/hexane

실험 절차

To 5 liters of ethanol containing 0.2 mole of sodium ethoxide is added slowly with stirring 0.1 mole each of phenol and 2,4,6-trichloro-7,8-dimethoxyquinazoline. The mixture is heated to boiling then allowed to stand at room temperature overnight, poured into ice-water, stirred 15 minutes and the precipitate collected by filtration. The cake is washed with water, then cold ethanol, dried and recrystallized from ethanol/hexane to obtain 2,6-dichloro-7,8-dimethoxy-4-ethoxyquinazoline.

출처