반응 #4418

반응 방정식

water

potassium tert.butoxide

methyl iodide

3,4-dihydro-6-(3,4 dimethoxyphenyl)-2-methylpyrimidin-4-one

→

3,4-dihydro-6-(3,4-dimethoxyphenyl)-2,3-dimethylpyrimidin-4-one

수율 65.3%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타Resulting mixture
2. 2
   추출extracted with ethyl acetate
3. 3
   기타The organic layer was chromatographed on silica gel eluting with chloroform

실험 절차

To a suspension of 3,4-dihydro-6-(3,4 dimethoxyphenyl)-2-methylpyrimidin-4-one (2.0 g) in N,N-dimethylformamide (20 ml) were added potassium tert.butoxide (1.08 g) and methyl iodide (1.0 ml), and stirred at ambient temperature for an hour. Resulting mixture was poured into water, and extracted with ethyl acetate. The organic layer was chromatographed on silica gel eluting with chloroform to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-2,3-dimethylpyrimidin-4-one (1.38 g).

출처