반응 #4416

반응 방정식

4-(4-chlorophenyl)butyl chloride

piperazine

→

1-[4-(4-chlorophenyl)butyl]piperazine

수율 46.3%

용매

ethanol

반응 조건

후처리

1. 1
   온도was refluxed overnight
2. 2
   기타Solvent was evaporated from the product
3. 3
   기타the residue was chromatographed twice on silica with the eluant
4. 4
   기타The first chromatography removed the bulk of the excess piperazine

실험 절차

A mixture of 26.4 g of 4-(4-chlorophenyl)butyl chloride, 86.1 g of anhydrous piperazine and 250 ml of reagent ethanol was refluxed overnight. Solvent was evaporated from the product and the residue was chromatographed twice on silica with the eluant being CH2Cl2 /CH3OH/ammonium hydroxide (45:5:1). The first chromatography removed the bulk of the excess piperazine, the second provided 15.2 g of 1-[4-(4-chlorophenyl)butyl]piperazine as a colorless oil which solidified on standing (m.p. 139°-145° C.).

출처