반응 #44153

반응 방정식

3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

triethylamine

methanesulfonyl chloride

→

title compound

N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-N-(methylsulfonyl)methanesulfonamide

용매

DCM

반응 조건

후처리

1. 1
   기타partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM
2. 2
   세척The organic layer was washed with water
3. 3
   기타dried
4. 4
   농축concentrated in vacuo
5. 5
   기타The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)]

실험 절차

To a stirred solution of 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (370 mg) and triethylamine (178 μL) in DCM (3 mL) was added methanesulfonyl chloride (33 L). The mixture was stirred for 18 h, then partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM. The organic layer was washed with water, dried and concentrated in vacuo. The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)] to give the title compound (342 mg).

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