반응 #44107

반응 방정식

hydrogen chloride

1,1-dimethylethyl-4-(6-fluoro-2-methyl-5-quinolinyl)-1-piperazinecarboxylate

→

title compound

수율 156.2%

6-Fluoro-2-methyl-5-(1-piperazinyl)quinoline

수율 156.2%

용매

dioxane

dioxane

반응 조건

후처리

1. 1
   농축The mixture was concentrated in vacuo
2. 2
   기타partitioned between aqueous sodium hydroxide solution and DCM
3. 3
   세척The combined organic phases were washed with brine
4. 4
   건조dried over sodium sulfate
5. 5
   농축concentrated

실험 절차

A solution of hydrogen chloride in dioxane (4M, 4 mL) was added to a solution of 1,1-dimethylethyl-4-(6-fluoro-2-methyl-5-quinolinyl)-1-piperazinecarboxylate (0.178 g) in dioxane (4 mL) at 0° C. The resulting mixture was warmed to room temperature and stirred for 15 h. The mixture was concentrated in vacuo and partitioned between aqueous sodium hydroxide solution and DCM. The combined organic phases were washed with brine, dried over sodium sulfate and concentrated to afford the title compound (198 mg, 100% yield).

출처