반응 #44099

반응 방정식

1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate

hydrochloric acid

→

title compound

수율 80.0%

2-Methyl-5-(1-piperazinyl)quinoline

수율 80.0%

용매

2-propanol

반응 조건

후처리

1. 1
   농축then concentrated
2. 2
   workup.ADDITIONWater (30 vol) was added
3. 3
   추출the solution was extracted with ethyl acetate (3×20 vol)
4. 4
   추출then extracted with dichloromethane (5×40 vol)
5. 5
   기타The combined organic extracts were dried
6. 6
   기타evaporated

실험 절차

To a solution of 1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate in 2-propanol (3 vol) was added dropwise hydrochloric acid (37%, 3 vol). The mixture was stirred at 40° C. for 1.5 hours then concentrated. Water (30 vol) was added and the solution was extracted with ethyl acetate (3×20 vol). The aqueous layer was basified with an aqueous sodium carbonate solution then extracted with dichloromethane (5×40 vol). The combined organic extracts were dried and evaporated to give the title compound as an off-white solid (80% th, 2 steps).

출처