반응 #440646

ord-c9a618e2e21b4dfc88878161f76a3197

반응 방정식

CCO
ethanol
O=C(O)c1ccc(-c2ccncc2)cc1
4-(4-pyridyl)benzoic acid
O=S(=O)(c1cc2cc(Br)ccc2[nH]1)N1CCNCC1
1-(5-bromoindol-2-ylsulphonyl)piperazine
CS(=O)(=O)O.O=C(c1ccc(-c2ccncc2)cc1)N1CCN(S(=O)(=O)c2cc3cc(Br)ccc3[nH]2)CC1
1-(5-bromoindol-2-ylsulphonyl)-4-[4-(4-pyridyl)benzoyl]piperazine methane sulphonic acid salt
O=C(c1ccc(-c2ccncc2)cc1)N1CCN(S(=O)(=O)c2cc3cc(Br)ccc3[nH]2)CC1
1-(5-Bromoindol-2-ylsulphonyl)-4-[4-(4-pyridyl)benzoyl]piperazine

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

By a method analogous to that described in Example 3 starting from 4-(4-pyridyl)benzoic acid (199 mg, 1 mmol) and 1-(5-bromoindol-2-ylsulphonyl)piperazine (344 mg, 1 mmol, 1 mol eq.), was prepared 1-(5-bromoindol-2-ylsulphonyl)-4-[4-(4-pyridyl)benzoyl]piperazine methane sulphonic acid salt, (155 mg), 1H NMR (d6-DMSO) 2.3 (s, 3H), 3.0-3.3 (broad d, 4H), 3.4-3.8 (broad d, 4H), 7.0 (d, 1H), 7.45 (s, 2H), 7.6 (d, 2H), 7.95 (s, 1H), 8.0 (d, 2H), 8.25 (d, 2H), 8.9 (d, 2H), 12.4 (s, 1H), signals were also present due to ethanol (0.15 mol equiv.); MS (M+H)+ 525/527.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06753331B1uspto-grants-2004_06