반응 #4400

반응 방정식

8-benzyloxy-3-(2-propynyloxymethyl)-2-methylimidazo[1,2-a]pyridine hydrochloride

sodium hydroxide

→

8-benzyloxy-3-(2-propynyloxymethyl)-2-methylimidazo[1,2-a]pyridine

수율 82.1%

용매

water

반응 조건

후처리

1. 1
   추출extracted with methylene chloride
2. 2
   세척The extract was washed with water
3. 3
   건조dried over magnesium sulfate
4. 4
   workup.ADDITIONtreated with activated charcoal
5. 5
   기타evaporated in vacuo
6. 6
   기타The residual solid was recrystallized from a mixture of methylene chloride and n-hexane

실험 절차

A solution of 8-benzyloxy-3-(2-propynyloxymethyl)-2-methylimidazo[1,2-a]pyridine hydrochloride (35.5 g) in hot water (700 ml) was neutralized with aqueous sodium hydroxide solution and extracted with methylene chloride. The extract was washed with water, dried over magnesium sulfate, treated with activated charcoal, and evaporated in vacuo. The residual solid was recrystallized from a mixture of methylene chloride and n-hexane to give 8-benzyloxy-3-(2-propynyloxymethyl)-2-methylimidazo[1,2-a]pyridine (26.03 g).

출처