반응 #43994

반응 방정식

1,4-Diethoxy-2,3-naphthalenedicarboxylic anhydride

ethyl (4-aminophenyl)acetate

water

→

ethyl[4-(4,9-diethoxy-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetate

용매

acetic acid

반응 조건

후처리

1. 1
   여과The white solid was filtered
2. 2
   세척washed with water
3. 3
   workup.DISSOLUTIONdissolved in dichloromethane (800 ml)
4. 4
   세척The solution was washed with water, brine
5. 5
   건조dried (MgSO4)
6. 6
   기타the solvent evaporated under vacuum

실험 절차

1,4-Diethoxy-2,3-naphthalenedicarboxylic anhydride (23.3 g, 81.5 mmol) and ethyl (4-aminophenyl)acetate (14.8 g, 82 mmol) were refluxed under nitrogen in acetic acid (160 ml) overnight. The mixture was cooled to room temperature and poured into water (1 L). The white solid was filtered, washed with water and dissolved in dichloromethane (800 ml). The solution was washed with water, brine and dried (MgSO4) and the solvent evaporated under vacuum to give ethyl[4-(4,9-diethoxy-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetate as an off-white solid, 33 g, 96%.

출처