반응 #439635

반응 방정식

Thionyl chloride

2-methyl-6-trifluoromethyl nicotinic acid

→

2-Methyl-6-(trifluoromethyl)-3-pyridinecarbonyl chloride

용매

toluene

반응 조건

후처리

1. 1
   온도the mixture was heated
2. 2
   온도at reflux for 3 hours
3. 3
   기타the solvent was removed under reduced pressure
4. 4
   기타Excess thionyl chloride was removed by azeotrope with toluene

실험 절차

Thionyl chloride (4.35 g, 36.5 mmol) was added to a mixture of 2-methyl-6-trifluoromethyl nicotinic acid (5.00 g, 24.4 mmol) in 75 mL of toluene and the mixture was heated at reflux for 3 hours. The reaction was cooled to room temperature and the solvent was removed under reduced pressure. Excess thionyl chloride was removed by azeotrope with toluene. The resultant acid chloride was used as is in Example 4, Step B.

출처