반응 #43926

반응 방정식

4-bromo-3,5-dimethylphenol

acetic anhydride

→

title compound

수율 128.9%

4-bromo-3,5-dimethylphenyl acetate

수율 128.9%

용매

hydrochloric acid

pyridine

반응 조건

후처리

1. 1
   온도cooled
2. 2
   추출extracted with ethyl acetate
3. 3
   세척The extract was washed with saturated brine
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   농축concentrated under reduced pressure

실험 절차

To a solution of 4-bromo-3,5-dimethylphenol (10.1 g, 50.0 mmol) in pyridine (13 mL) was added acetic anhydride (7.66 g, 38.6 mmol), and the mixture was stirred at 50° C. for 30 min. The reaction mixture was ice-cooled, diluted with 0.5 M hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (12.1 g, yield 99%) as a yellow oil.

출처