반응 #438861

반응 방정식

N-(3,4-Dimethoxy-phenyl)-4-fluoro-benzenesulfonamide

benzyl bromide

potassium carbonate

→

desired product

수율 79.1%

N-Benzyl-N-(3,4-dimethoxy-phenyl)-4-fluoro-benzenesulfonamide

수율 79.1%

용매

acetone

반응 조건

후처리

1. 1
   기타The undissolved solids were removed by filtration
2. 2
   농축the mother liquor was concentrated
3. 3
   기타This gum was triturated with hexanes

실험 절차

N-(3,4-Dimethoxy-phenyl)-4-fluoro-benzenesulfonamide (0.51 g, 1.61 mM) was added to a solution of benzyl bromide (0.57 g, 4.82 mM) and potassium carbonate (0.66 g, 4.82 mM)in anhyrous acetone(10 ml). The reaction was stirred overnight. The undissolved solids were removed by filtration and the mother liquor was concentrated. This gum was triturated with hexanes to afford 0.52 g of the desired product as an off-white solid. H1 NMR(CDCl3) δ 3.66(s, 3H), 3.81(s, 3H), 6.42(m, 2H), 6.66(d, 1H, J=8.70 Hz), 7.23(m, 7H), 7.71(m, 2H). MS(ES) m/z 401.9; (MH+); HRMS for C21H20SFNO4: 401.1094.

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