반응 #43885

반응 방정식

Tartaric acid

oseltamivir

→

oseltamivir tartrate

수율 97.6%

용매

ethyl acetate

반응 조건

후처리

1. 1
   온도slowly cooled to 30° C. in 1 hour
2. 2
   여과Filtered the solid
3. 3
   세척washed with 70 ml of ethyl acetate
4. 4
   기타dried

실험 절차

Tartaric acid (5 gm) is added to the solution of oseltamivir free base (9 gm, HPLC purity: 95.8%) in ethyl acetate (50 ml) at 25-30° C., the contents are heated to 50° C. and then slowly cooled to 30° C. in 1 hour. Filtered the solid, washed with 70 ml of ethyl acetate and dried to yield 13 gm of oseltamivir tartrate (HPLC purity: 97.2%).

출처