반응 #4387

반응 방정식

2-amino-3-hydroxypyridine

2-methylbenzyl chloride

→

2-amino-3-(2-methylbenzyloxy)pyridine

용매

sodium hydroxide

methylene chloride

반응 조건

후처리

1. 1
   기타the organic layer was separated
2. 2
   추출the aqueous layer was extracted with methylene chloride
3. 3
   세척The combined extracts were washed with saturated sodium chloride aqueous solution
4. 4
   건조dried over magnesium sulfate
5. 5
   기타evaporated in vacuo
6. 6
   기타The crystalline residue was recrystallized from ethyl acetate

실험 절차

To a mixture of 2-amino-3-hydroxypyridine (7 g) and Adogen 464 (Trademark: prepared by Aldrich Chemical Co.) (0.4 g) in 40% aqueous sodium hydroxide (32 ml) and methylene chloride (32 ml) was added 2-methylbenzyl chloride (8.42 ml) at ambient temperature. After being stirred for 24 hours, the organic layer was separated and the aqueous layer was extracted with methylene chloride. The combined extracts were washed with saturated sodium chloride aqueous solution, dried over magnesium sulfate, and evaporated in vacuo. The crystalline residue was recrystallized from ethyl acetate to give 2-amino-3-(2-methylbenzyloxy)pyridine (7.56 g).

출처