반응 #43866

반응 방정식

3-Chloro-benzoyl chloride

(5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

DIEA

→

subtitle compound

{5-[Benzyl-(3-chloro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

용매

HCl

CH2Cl2

반응 조건

후처리

1. 1
   여과filtered through an Extrelut column
2. 2
   세척The Extrelut column was washed with CH2Cl2
3. 3
   농축the filtrate was concentrated

실험 절차

3-Chloro-benzoyl chloride (46 μL, 0.36 mmol) was added to a solution of (5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester (45 mg, 0.12 mmol), DIEA (41 μL, 0.24 mmol) and DMAP (15 mg, 0.12 mmol) in CH2Cl2 (1 mL), and stirred overnight at room temperature. The reaction solution was diluted with aqueous HCl (1.0 M) and filtered through an Extrelut column. The Extrelut column was washed with CH2Cl2, and the filtrate was concentrated to afford the subtitle compound that was used without further purification. MS calculated for C30H32ClN3O3+H: 518, observed: 518.

출처