반응 #43826

반응 방정식

2,3-Dichlorobenzyl chloride

K2CO3

[5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

→

{5-[(2,3-Dichloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-l-yl}-acetic acid tert-butyl ester

용매

EtOAc

H2O

CH3CN

반응 조건

후처리

1. 1
   여과filtered through an Extrelut column
2. 2
   세척The column was washed with EtOAc
3. 3
   농축the filtrate was concentrated
4. 4
   기타The crude product was carried onto the next reaction without any further purification or characterization

실험 절차

2,3-Dichlorobenzyl chloride (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

출처