반응 #43811

반응 방정식

product

(5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

NaOH

→

title compound

(5 -tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid

용매

DCM

ethanol

반응 조건

후처리

1. 1
   추출extracted with water
2. 2
   추출extracted with DCM
3. 3
   세척The organic layer was washed with water
4. 4
   농축concentrated
5. 5
   기타purified by preparative LCMS

실험 절차

The product of step d.) was dissolved in 3 mL ethanol, treated with 1 M NaOH (500 μL), and heated to 70° C. for one hour. The reaction was diluted in DCM and extracted with water. The aqueous layer was acidified with 1 M HCl and extracted with DCM. The organic layer was washed with water, concentrated and purified by preparative LCMS to give the title compound. MS: ESI (positive): 334 (M+H).

출처