반응 #43804

반응 방정식

Pyridine

4-fluoro-3-nitro-phenylamine

4-fluoro-benzenesulfonyl chloride

→

sub-title compound

수율 80.7%

4-Fluoro-N-(4-fluoro-3 -nitro-phenyl)-benzenesulfonamide

수율 80.7%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The reaction was then partitioned between water and DCM
2. 2
   세척The organic layer was washed several times with water
3. 3
   농축concentrated
4. 4
   기타Recrystalization from ethanol/water

실험 절차

Pyridine (500 uL, 6.19 mmol) was added to a solution of 4-fluoro-3-nitro-phenylamine (1 g, 6.41 mmol) and 4-fluoro-benzenesulfonyl chloride (1.2 g, 6.19 mmol) in dichloromethane (DCM) (20 mL) and the reaction was stirred at room temperature overnight. The reaction was then partitioned between water and DCM. The organic layer was washed several times with water and concentrated. Recrystalization from ethanol/water gave 1.57 g of the sub-title compound as tan crystals.

출처