반응 #43793

반응 방정식

Toluene

MeOH

7-(benzyloxy)-4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinoline

→

product

수율 100.0%

4-(7-(Benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorobenzenamine

수율 100.0%

용매

EtOAc

반응 조건

후처리

1. 1
   workup.STIRRINGstirred for 20 minutes
2. 2
   여과filtered the catalyst
3. 3
   농축the filtrate solution was concentrated in vacuo

실험 절차

A mixture of 7-(benzyloxy)-4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinoline (125 mg, 0.3 mmol) and PtO2 in EtOAc (15 mL) was stirred at rt under 1 atm of H2 gas for 2 h. Toluene (4 mL) and MeOH (5 mL) were added to the reaction mixture, stirred for 20 minutes, filtered the catalyst, and the filtrate solution was concentrated in vacuo to obtain the product (117 mg, 100%) as a white solid. 1H NMR (DMF-d7) δ 8.52 (d, 1H, J=5.0 Hz), 7.68-6.67 (m, 12H), 6.48 (d, 1H, J=5.0 Hz), 5.38 (s, 2H), 4.02 (s, 3H).

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