반응 #437855

반응 방정식

dibutyltin dilaurate

(R)-mandelic acid

4-chlorophenyl isocyanate

water

→

(R)-(4-chlorophenylcarbamoyloxy)phenylacetic acid

용매

dichloromethane

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   기타The organic phase is evaporated

실험 절차

1.1 400 mg (0.63 mmol) of dibutyltin dilaurate are added to a solution of 10.0 g (65.7 mmol) of (R)-mandelic acid and 10.0 g (65.1 mmol) of 4-chlorophenyl isocyanate in 100 ml of dichloromethane, and the mixture is stirred at room temperature for 24 hours. The reaction mixture is introduced into water and extracted with ethyl acetate. The organic phase is evaporated, giving (R)-(4-chlorophenylcarbamoyloxy)phenylacetic acid as a colourless solid; ESI 306.

출처