반응 #437843

반응 방정식

3-Hydroxy-4-methoxy-3′-benzyloxypicolinanilide

acetic anhydride

→

title compound

수율 67.0%

3-Acetyloxy-4-methoxy-3′-benzyloxypicolinanilide

수율 67.0%

반응 조건

후처리

1. 1
   농축The reaction solution was concentrated under the reduced pressure
2. 2
   추출The concentrate was extracted with chloroform
3. 3
   세척by washing with a saturated sodium hydrogencarbonate solution
4. 4
   추출The washed extract
5. 5
   건조was then dried over anhydrous sodium sulfate
6. 6
   농축was then concentrated under the reduced pressure
7. 7
   기타The residue was purified by column chromatography on silica gel (chloroform)

실험 절차

3-Hydroxy-4-methoxy-3′-benzyloxypicolinanilide (20 mg) was dissolved in 1 ml of acetic anhydride, and a reaction was allowed to proceed at 80° C. for 3 hr. The reaction solution was concentrated under the reduced pressure. The concentrate was extracted with chloroform, followed by washing with a saturated sodium hydrogencarbonate solution and then with saturated brine. The washed extract was then dried over anhydrous sodium sulfate, and was then concentrated under the reduced pressure. The residue was purified by column chromatography on silica gel (chloroform) to give 15 mg (yield 67%) of title compound.

출처