반응 #437822

반응 방정식

3-Benzyloxy-4-methoxy-4′-phenoxypicolinanilide

→

title compound

수율 81.3%

3-Hydroxy-4-methoxy-4′-phenoxypicolinanilide

수율 81.3%

용매

ethanol

반응 조건

후처리

1. 1
   기타to prepare a suspension
2. 2
   기타was subjected to catalytic reduction under atmospheric conditions overnight
3. 3
   여과The reaction solution was filtered
4. 4
   농축the filtrate was concentrated under the reduced pressure
5. 5
   workup.DISSOLUTIONThe residue was dissolved in a water-methanol mixed solution
6. 6
   기타was recrystallized

실험 절차

3-Benzyloxy-4-methoxy-4′-phenoxypicolinanilide (0.64 g, 1.5 mmol) was mixed with ethanol (4 ml) to prepare a suspension. To this suspension was added 64 mg of 10% palladium-carbon. The mixture was subjected to catalytic reduction under atmospheric conditions overnight. The reaction solution was filtered, and the filtrate was concentrated under the reduced pressure. The residue was dissolved in a water-methanol mixed solution, and was recrystallized to give 0.41 g (yield 81%) of the title compound.

출처