반응 #437821

반응 방정식

3-Benzyloxy-4-methoxypicolinic acid

carbonyldiimidazole

DMF

DMF

4-phenoxyaniline

→

title compound

수율 71.3%

3-Benzyloxy-4-methoxy-4′-phenoxypicolinanilide

수율 71.3%

용매

Water

반응 조건

후처리

1. 1
   추출followed by extraction with ethyl acetate
2. 2
   건조The organic layer was dried over anhydrous sodium sulfate
3. 3
   농축the dried organic layer was concentrated under the reduced pressure
4. 4
   기타The residue was purified by column chromatography on silica gel (ethyl acetate-n-hexane)

실험 절차

3-Benzyloxy-4-methoxypicolinic acid (0.65 g, 2.5 mmol) and 0.50 g (3.0 mmol) of carbonyldiimidazole were mixed into anhydrous DMF to prepare a suspension (8 ml). An anhydrous DMF solution (2 ml) of 0.56 g (3.0 mmol) of 4-phenoxyaniline was added dropwise to this suspension, and a reaction was allowed to proceed at room temperature overnight. Water (10 ml) was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and the dried organic layer was concentrated under the reduced pressure. The residue was purified by column chromatography on silica gel (ethyl acetate-n-hexane) to give 0.76 g (yield 71%) of the title compound.

출처