반응 #4377

반응 방정식

iodine

1-(3-methoxyphenyl)butane-3-one

→

1-(2-iodo-5-methoxyphenyl)butane-3-one

수율 82.3%

용매

acetic acid

반응 조건

후처리

1. 1
   기타The silver iodide was removed by filtration
2. 2
   세척washed with acetic acid
3. 3
   기타The filtrate was partitioned between ether and water
4. 4
   세척The ether layer was washed with water, sodium bicarbonate solution and sodium thiosulfate solution
5. 5
   건조The ether solution was dried with MgSO4
6. 6
   기타evaporated to dryness in vacuo

실험 절차

Samples of iodine (42.4 g, 0.167 mole) and silver acetate (27.87 g, 0.167 mole) were added in portions to a solution of 29.8 g (0.167 mole) of 1-(3-methoxyphenyl)butane-3-one in 167 ml of glacial acetic acid. The mixture was stirred one hour. The silver iodide was removed by filtration and washed with acetic acid. The filtrate was partitioned between ether and water. The ether layer was washed with water, sodium bicarbonate solution and sodium thiosulfate solution. The ether solution was dried with MgSO4 and evaporated to dryness in vacuo. There was obtained 41.8 g (82% yield) of oily 1-(2-iodo-5-methoxyphenyl)butane-3-one.

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